대장암 항암치료 시 시툭시마브의 표적약물전달을 위한 펄스하이푸의 역할에 대한 동물실험연구
- 주저자 : Park MJ, Kim YS(김영선), Yang J, Sun WC, Park H, Chae SY, Namgun MS, Choi KS
- 영문 제목 : Pulsed High-intensity Focused Ultrasound Therapy Enhances Targeted Delivery of Cetuximab to Colon Cancer Xenograft Model in Mice
- 한글 제목 : 대장암 항암치료 시 시툭시마브의 표적약물전달을 위한 펄스하이푸의 역할에 대한 동물실험연구
- 저널 : Ultrasound Med Biol
- 연도 : 2013
- 권 / 쪽 : 39 / 292-299
- 초록 : Our aim was to evaluate whether pulsed high-intensity focused ultrasound (HIFU) therapy enhances the effect of an epidermal growth factor receptor-targeted chemotherapeutic drug, cetuximab, in treating human colon cancer xenografts in a mouse model. Balb/c nude mice with subcutaneous xenografts of HT-29 cells were randomly categorized into control (n = 9), pulsed HIFU alone (n = 10), cetuximab monotherapy (n = 8) or combined pulsed HIFU and cetuximab therapy (n = 9) group. Cetuximab, pulsed HIFU therapy, or both were administered three times per week starting from day 8 after tumor cell injection. Based on tumor growth curves up to 34 days, the combination therapy group showed more suppressed tumor growth than all other groups (p < 0.05). The final relative tumor volumes were 5.4 ± 2.1, 5.2 ± 1.3, 4.8 ± 1.8, and 3.1 ± 0.9 for control, pulsed HIFU alone, cetuximab monotherapy, and combination therapy groups, respectively. In conclusion, pulsed HIFU therapy appears to enhance the anti-tumor effect of epidermal growth factor receptor-targeted cetuximab on human colon cancer xenograft models in mice.